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Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
Lin28 acts as a repressor of microRNA processing and as a post-transcriptional regulatory factor for a subset of mRNAs. Here we report that in human embryonic stem cells Lin28 facilitates the expression of the pivotal pluripotency factor Oct4 at the post-transcriptional level. We provide evidence th...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831306/ https://ncbi.nlm.nih.gov/pubmed/19966271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1071 |
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