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Chaperoning of a Replicative Polymerase onto a Newly-Assembled DNA-Bound Sliding Clamp by the Clamp Loader
Cellular replicases contain a multiprotein ATPase that loads a sliding clamp processivity factor onto DNA. We reveal a new role for a clamp loader: chaperoning of the replicative polymerase onto a clamp newly bound to DNA. We show that chaperoning confers distinct advantages, including marked accele...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830912/ https://ncbi.nlm.nih.gov/pubmed/20188667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.013 |
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