Chaperoning of a Replicative Polymerase onto a Newly-Assembled DNA-Bound Sliding Clamp by the Clamp Loader

Cellular replicases contain a multiprotein ATPase that loads a sliding clamp processivity factor onto DNA. We reveal a new role for a clamp loader: chaperoning of the replicative polymerase onto a clamp newly bound to DNA. We show that chaperoning confers distinct advantages, including marked accele...

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Bibliographic Details
Main Authors: Downey, Christopher D., McHenry, Charles S.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830912/
https://ncbi.nlm.nih.gov/pubmed/20188667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.013
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