Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice

We sought genetic evidence for the involvement of neuronal vascular endothelial growth factor (VEGF) in amyotrophic lateral sclerosis (ALS). Mice expressing human ALS mutant superoxide dismutase-1 (SOD1) were crossed with mice that overexpress VEGF in neurons (VEGF(+/+)). We report that SOD1(G93A)/V...

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Autori principali: Wang, Yaoming, Ou Mao, Xiao, Xie, Lin, Banwait, Surita, Marti, Hugo H., Greenberg, David A., Jin, Kunlin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2007
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830908/
https://ncbi.nlm.nih.gov/pubmed/17215390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4433-06.2007
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