Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice

We sought genetic evidence for the involvement of neuronal vascular endothelial growth factor (VEGF) in amyotrophic lateral sclerosis (ALS). Mice expressing human ALS mutant superoxide dismutase-1 (SOD1) were crossed with mice that overexpress VEGF in neurons (VEGF(+/+)). We report that SOD1(G93A)/V...

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Detalhes bibliográficos
Main Authors: Wang, Yaoming, Ou Mao, Xiao, Xie, Lin, Banwait, Surita, Marti, Hugo H., Greenberg, David A., Jin, Kunlin
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830908/
https://ncbi.nlm.nih.gov/pubmed/17215390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4433-06.2007
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