Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice

We sought genetic evidence for the involvement of neuronal vascular endothelial growth factor (VEGF) in amyotrophic lateral sclerosis (ALS). Mice expressing human ALS mutant superoxide dismutase-1 (SOD1) were crossed with mice that overexpress VEGF in neurons (VEGF(+/+)). We report that SOD1(G93A)/V...

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Main Authors: Wang, Yaoming, Ou Mao, Xiao, Xie, Lin, Banwait, Surita, Marti, Hugo H., Greenberg, David A., Jin, Kunlin
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2007
主題:
Brief Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830908/
https://ncbi.nlm.nih.gov/pubmed/17215390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4433-06.2007
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