Sequence Variation in DDAH1 and DDAH2 Genes Is Strongly and Additively Associated with Serum ADMA Concentrations in Individuals with Type 2 Diabetes

BACKGROUND: Asymmetric dimethylarginine (ADMA), present in human serum, is an endogenous inhibitor of nitric oxide synthase and contributes to vascular disease. Dimethylarginine dimethylaminohydrolase (DDAH) is an ADMA degrading enzyme that has two isoforms: DDAHI and DDAHII. We sought to determine...

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Bibliografiske detaljer
Main Authors: Abhary, Sotoodeh, Burdon, Kathryn P., Kuot, Abraham, Javadiyan, Shahrbanou, Whiting, Malcolm J., Kasmeridis, Nicholas, Petrovsky, Nikolai, Craig, Jamie E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830883/
https://ncbi.nlm.nih.gov/pubmed/20209122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009462
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