Sequence Variation in DDAH1 and DDAH2 Genes Is Strongly and Additively Associated with Serum ADMA Concentrations in Individuals with Type 2 Diabetes

BACKGROUND: Asymmetric dimethylarginine (ADMA), present in human serum, is an endogenous inhibitor of nitric oxide synthase and contributes to vascular disease. Dimethylarginine dimethylaminohydrolase (DDAH) is an ADMA degrading enzyme that has two isoforms: DDAHI and DDAHII. We sought to determine...

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Detalhes bibliográficos
Main Authors: Abhary, Sotoodeh, Burdon, Kathryn P., Kuot, Abraham, Javadiyan, Shahrbanou, Whiting, Malcolm J., Kasmeridis, Nicholas, Petrovsky, Nikolai, Craig, Jamie E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830883/
https://ncbi.nlm.nih.gov/pubmed/20209122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009462
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