Sequence Variation in DDAH1 and DDAH2 Genes Is Strongly and Additively Associated with Serum ADMA Concentrations in Individuals with Type 2 Diabetes

BACKGROUND: Asymmetric dimethylarginine (ADMA), present in human serum, is an endogenous inhibitor of nitric oxide synthase and contributes to vascular disease. Dimethylarginine dimethylaminohydrolase (DDAH) is an ADMA degrading enzyme that has two isoforms: DDAHI and DDAHII. We sought to determine...

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Autori principali: Abhary, Sotoodeh, Burdon, Kathryn P., Kuot, Abraham, Javadiyan, Shahrbanou, Whiting, Malcolm J., Kasmeridis, Nicholas, Petrovsky, Nikolai, Craig, Jamie E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830883/
https://ncbi.nlm.nih.gov/pubmed/20209122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009462
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