Sequence Variation in DDAH1 and DDAH2 Genes Is Strongly and Additively Associated with Serum ADMA Concentrations in Individuals with Type 2 Diabetes

BACKGROUND: Asymmetric dimethylarginine (ADMA), present in human serum, is an endogenous inhibitor of nitric oxide synthase and contributes to vascular disease. Dimethylarginine dimethylaminohydrolase (DDAH) is an ADMA degrading enzyme that has two isoforms: DDAHI and DDAHII. We sought to determine...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Abhary, Sotoodeh, Burdon, Kathryn P., Kuot, Abraham, Javadiyan, Shahrbanou, Whiting, Malcolm J., Kasmeridis, Nicholas, Petrovsky, Nikolai, Craig, Jamie E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2010
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830883/
https://ncbi.nlm.nih.gov/pubmed/20209122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009462
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