Performance Metrics for Liquid Chromatography-Tandem Mass Spectrometry Systems in Proteomics Analyses

A major unmet need in LC-MS/MS-based proteomics analyses is a set of tools for quantitative assessment of system performance and evaluation of technical variability. Here we describe 46 system performance metrics for monitoring chromatographic performance, electrospray source stability, MS1 and MS2...

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Autori principali: Rudnick, Paul A., Clauser, Karl R., Kilpatrick, Lisa E., Tchekhovskoi, Dmitrii V., Neta, Pedatsur, Blonder, Nikša, Billheimer, Dean D., Blackman, Ronald K., Bunk, David M., Cardasis, Helene L., Ham, Amy-Joan L., Jaffe, Jacob D., Kinsinger, Christopher R., Mesri, Mehdi, Neubert, Thomas A., Schilling, Birgit, Tabb, David L., Tegeler, Tony J., Vega-Montoto, Lorenzo, Variyath, Asokan Mulayath, Wang, Mu, Wang, Pei, Whiteaker, Jeffrey R., Zimmerman, Lisa J., Carr, Steven A., Fisher, Susan J., Gibson, Bradford W., Paulovich, Amanda G., Regnier, Fred E., Rodriguez, Henry, Spiegelman, Cliff, Tempst, Paul, Liebler, Daniel C., Stein, Stephen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2010
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830836/
https://ncbi.nlm.nih.gov/pubmed/19837981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900223-MCP200
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