Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1) is caused by a CTG expansion within the 3′-untranslated region of the DMPK gene. The predominant mechanism of pathogenesis is a toxic gain of function of CUG repeat containing RNA transcribed from the expanded allele. The molecular mechanisms by which the RNA containi...

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Hauptverfasser: Koshelev, Misha, Sarma, Satyam, Price, Roger E., Wehrens, Xander H.T., Cooper, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830830/
https://ncbi.nlm.nih.gov/pubmed/20051426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp570
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