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PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1
Cardiac complications are a common cause of death in individuals with the inherited multisystemic disease myotonic dystrophy type 1 (DM1). A characteristic molecular feature of DM1 is misregulated alternative splicing due to disrupted functioning of the splicing regulators muscleblind-like 1 (MBNL1)...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2786786/ https://ncbi.nlm.nih.gov/pubmed/19907076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37976 |
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