PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1

Cardiac complications are a common cause of death in individuals with the inherited multisystemic disease myotonic dystrophy type 1 (DM1). A characteristic molecular feature of DM1 is misregulated alternative splicing due to disrupted functioning of the splicing regulators muscleblind-like 1 (MBNL1)...

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Autori principali: Wang, Guey-Shin, Kuyumcu-Martinez, Muge N., Sarma, Satyam, Mathur, Nitin, Wehrens, Xander H.T., Cooper, Thomas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786786/
https://ncbi.nlm.nih.gov/pubmed/19907076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37976
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