Chargement en cours...
Increased steady state levels of CUGBP1 in Myotonic Dystrophy 1 are due to PKC-mediated hyper-phosphorylation
The genetic basis of myotonic dystrophy type 1 (DM1) is a CTG expansion in the 3' untranslated region (UTR) of DMPK. The pathogenic mechanism involves an RNA gain of function in which the repeat containing transcripts accumulate in nuclei and alter the functions of RNA binding proteins such as...
Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2007
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2083558/ https://ncbi.nlm.nih.gov/pubmed/17936705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.07.027 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|