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Increased steady state levels of CUGBP1 in Myotonic Dystrophy 1 are due to PKC-mediated hyper-phosphorylation
The genetic basis of myotonic dystrophy type 1 (DM1) is a CTG expansion in the 3' untranslated region (UTR) of DMPK. The pathogenic mechanism involves an RNA gain of function in which the repeat containing transcripts accumulate in nuclei and alter the functions of RNA binding proteins such as...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2083558/ https://ncbi.nlm.nih.gov/pubmed/17936705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.07.027 |
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