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Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish. We found that the multi-di...

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Hlavní autoři: Rihel, Jason, Prober, David A., Arvanites, Anthony, Lam, Kelvin, Zimmerman, Steven, Jang, Sumin, Haggarty, Stephen J., Kokel, David, Rubin, Lee L., Peterson, Randall T., Schier, Alexander F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830481/
https://ncbi.nlm.nih.gov/pubmed/20075256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1183090
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