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Reciprocally Coupled Residues Crucial for Protein Kinase Pak2 Activity Calculated by Statistical Coupling Analysis

Regulation of Pak2 activity involves at least two mechanisms: (i) phosphorylation of the conserved Thr(402) in the activation loop and (ii) interaction of the autoinhibitory domain (AID) with the catalytic domain. We collected 482 human protein kinase sequences from the kinome database and globally...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hsu, Yuan-Hao, Traugh, Jolinda A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830475/
https://ncbi.nlm.nih.gov/pubmed/20209159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009455
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