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CaMK-II Promotes Focal Adhesion Turnover and Cell Motility by Inducing Tyrosine Dephosphorylation of FAK and Paxillin

Transient elevations in Ca(2+) have previously been shown to promote focal adhesion disassembly and cell motility through an unknown mechanism. In this study, evidence is provided to show that CaMK-II, a Ca(2+)/calmodulin dependent protein kinase, influences fibroblast adhesion and motility. TIRF mi...

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Main Authors: Easley, Charles A., Brown, Claire M., Horwitz, Alan F., Tombes, Robert M.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830206/
https://ncbi.nlm.nih.gov/pubmed/18613116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cm.20294
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