CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs

Sepsis is a severe infection-induced systemic inflammatory syndrome. Inhibition of downstream inflammatory mediators of sepsis, e.g., TNF-α, has failed in clinical trials. The aim of this study was to investigate the effects of inhibiting CD14, a key upstream innate immunity molecule, on the early i...

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Hlavní autoři: Thorgersen, Ebbe Billmann, Hellerud, Bernt Christian, Nielsen, Erik Waage, Barratt-Due, Andreas, Fure, Hilde, Lindstad, Julie Katrine, Pharo, Anne, Fosse, Erik, Tønnessen, Tor Inge, Johansen, Harald Thidemann, Castellheim, Albert, Mollnes, Tom Eirik
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2010
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830134/
https://ncbi.nlm.nih.gov/pubmed/19841036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-140798
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