Molecularly Evolved Thymidylate Synthase Inhibits 5-Fluorodeoxyuridine Toxicity in Human Hematopoietic Cells

Thymidylate synthase (TS) inhibitors, such as 5-fluorouracil (5-FU) and 5-fluorodeoxyuridine (5-FUdR), are amongst the most frequently used chemotherapeutic drugs available, although their efficacy is often limited by myelotoxicity. An emerging strategy for overcoming bone marrow toxicity involves e...

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Detalhes bibliográficos
Main Authors: Bielas, Jason H., Schmitt, Michael W., Icreverzi, Amalia, Ericson, Nolan G., Loeb, Lawrence A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829455/
https://ncbi.nlm.nih.gov/pubmed/19694534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.053
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