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ATR activation and replication fork restart are defective in FANCM-deficient cells

Fanconi anaemia is a chromosomal instability disorder associated with cancer predisposition and bone marrow failure. Among the 13 identified FA gene products only one, the DNA translocase FANCM, has homologues in lower organisms, suggesting a conserved function in DNA metabolism. However, a precise...

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Bibliografiske detaljer
Main Authors: Schwab, Rebekka A, Blackford, Andrew N, Niedzwiedz, Wojciech
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829160/
https://ncbi.nlm.nih.gov/pubmed/20057355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.385
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