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Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster
Endocytosis of the transmembrane ligands Delta (Dl) and Serrate (Ser) is required for the proper activation of Notch receptors. The E3 ubiquitin ligases Mindbomb1 (Mib1) and Neuralized (Neur) regulate the ubiquitination of Dl and Ser and thereby promote both ligand endocytosis and Notch receptor act...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2828914/ https://ncbi.nlm.nih.gov/pubmed/20176925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200907116 |
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