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Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

VEGF can be secreted in multiple isoforms with variable affinity for extracellular proteins and different abilities to induce vascular morphogenesis, but the molecular mechanisms behind these effects remain unclear. Here, we show molecular distinctions between signaling initiated from soluble versus...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Tom T., Luque, Alfonso, Lee, Sunyoung, Anderson, Sean M., Segura, Tatiana, Iruela-Arispe, M. Luisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828913/
https://ncbi.nlm.nih.gov/pubmed/20176926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906044
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