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Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

VEGF can be secreted in multiple isoforms with variable affinity for extracellular proteins and different abilities to induce vascular morphogenesis, but the molecular mechanisms behind these effects remain unclear. Here, we show molecular distinctions between signaling initiated from soluble versus...

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Hlavní autoři: Chen, Tom T., Luque, Alfonso, Lee, Sunyoung, Anderson, Sean M., Segura, Tatiana, Iruela-Arispe, M. Luisa
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828913/
https://ncbi.nlm.nih.gov/pubmed/20176926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906044
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