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Characterization, purification, and affinity labeling of the brain [3H]glibenclamide-binding protein, a putative neuronal ATP-regulated K+ channel.

Sulfonylurea and particularly glibenclamide are potent blockers of ATP-regulated K+ channels in insulin-secreting cells. A very good correlation exists between binding of sulfonylurea to brain and insulinoma cell membranes. The [3H]glibenclamide-binding component from pig brain microsomes was solubi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Bernardi, H, Fosset, M, Lazdunski, M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282872/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3144003/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.24.9816
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