Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling

OBJECTIVE: Ceramide is now recognized as a negative regulator of insulin signaling by impairing protein kinase B (PKB)/Akt activation. In different cells, two distinct mechanisms have been proposed to mediate ceramide inhibition of PKB/Akt: one involving atypical protein kinase C zeta (PKCζ) and the...

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Bibliografiske detaljer
Main Authors: Blouin, Cédric M., Prado, Cécilia, Takane, Karen K., Lasnier, Françoise, Garcia-Ocana, Adolfo, Ferré, Pascal, Dugail, Isabelle, Hajduch, Eric
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2010
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828662/
https://ncbi.nlm.nih.gov/pubmed/19959757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0897
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