Hyperglycemia Impairs Proteasome Function by Methylglyoxal

OBJECTIVE: The ubiquitin-proteasome system is the main degradation machinery for intracellularly altered proteins. Hyperglycemia has been shown to increase intracellular levels of the reactive dicarbonyl methylglyoxal (MGO) in cells damaged by diabetes, resulting in modification of proteins and alte...

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Main Authors: Queisser, Markus A., Yao, Dachun, Geisler, Sven, Hammes, Hans-Peter, Lochnit, Günter, Schleicher, Erwin D., Brownlee, Michael, Preissner, Klaus T.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2010
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828656/
https://ncbi.nlm.nih.gov/pubmed/20009088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1565
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