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Hyperglycemia Impairs Proteasome Function by Methylglyoxal
OBJECTIVE: The ubiquitin-proteasome system is the main degradation machinery for intracellularly altered proteins. Hyperglycemia has been shown to increase intracellular levels of the reactive dicarbonyl methylglyoxal (MGO) in cells damaged by diabetes, resulting in modification of proteins and alte...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Diabetes Association
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2828656/ https://ncbi.nlm.nih.gov/pubmed/20009088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1565 |
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