Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel.

Results of studies of hypophysectomized rats suggest that growth hormone serves as a final common mediator through which gonadal steroids and other modifiers of pituitary function alter the expression of gender-specific liver genes such as the sexually dimorphic pair of cytochrome P-450 isozymes, ma...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Guzelian, P S, Li, D, Schuetz, E G, Thomas, P, Levin, W, Mode, A, Gustafsson, J A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282865/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3200857/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.24.9783
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