Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons

In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the inability to detect dehydroepiandrosterone synthase, P45017α. In adult male rat hippocampal formation, significant localization was demonstrated for both cytochromes P45017α...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hojo, Yasushi, Hattori, Taka-aki, Enami, Taihei, Furukawa, Aizo, Suzuki, Kumiko, Ishii, Hiro-taka, Mukai, Hideo, Morrison, John H., Janssen, William G. M., Kominami, Shiro, Harada, Nobuhiro, Kimoto, Tetsuya, Kawato, Suguru
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321772/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694190/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2630225100
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