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Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons

In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the inability to detect dehydroepiandrosterone synthase, P45017α. In adult male rat hippocampal formation, significant localization was demonstrated for both cytochromes P45017α...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Hojo, Yasushi, Hattori, Taka-aki, Enami, Taihei, Furukawa, Aizo, Suzuki, Kumiko, Ishii, Hiro-taka, Mukai, Hideo, Morrison, John H., Janssen, William G. M., Kominami, Shiro, Harada, Nobuhiro, Kimoto, Tetsuya, Kawato, Suguru
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321772/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694190/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2630225100
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