Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity

The central nervous system is susceptible to the modulation of various neurophysiological processes by the cytochrome P450 enzyme (CYP), which plays a crucial role in the metabolism of neurosteroids. The antiepileptic drug phenytoin (PHT) has been observed to induce neuronal side effects in patients...

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Principais autores:	Shuai Zhang, Tingting Wang, Ye Feng, Fei Li, Aijuan Qu, Xiuchen Guan, Hui Wang, Dan Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-12-01
coleção:	Journal of Pharmaceutical Analysis
Assuntos:	Pregnenolone 16α-carbonitrile Pregnane X receptor Hippocampus Glucocorticoid receptor Phenytoin sodium Neurotoxicity
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2095177923001624
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