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Asymmetric Synthesis of the Core of AMPTD, the Key Amino Acid of Microsclerodermins F-I

We report a stereoselective synthesis of the five consecutive stereocenters of AMPTD in seven steps. Highlights include an Evans glycolate aldol reaction, the use of a Weinreb amide as an aldehyde masking group, and a Mannich reaction with an Ellman-type chiral sulfimine.

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Bibliografiske detaljer
Main Authors: Burnett, Cameron M., Williams, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828631/
https://ncbi.nlm.nih.gov/pubmed/20191096
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