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Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells.

A chimeric toxin composed of human interleukin 6 (IL-6) attached to a portion of Pseudomonas exotoxin (PE) devoid of its own cell recognition domain has been produced in Escherichia coli. The fusion protein (IL-6-PE40) is cytotoxic to a human myeloma cell line expressing IL-6 receptors but has no ef...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Siegall, C B, Chaudhary, V K, FitzGerald, D J, Pastan, I
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282855/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3264406/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.24.9738
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