Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells

Goniothalamin (GTN) isolated from Goniothalamus sp. has been demonstrated to induce apoptosis in a variety of cancer cell lines including Jurkat T leukemia cells. However, the mechanism of GTN-induced apoptosis upstream of mitochondria is still poorly defined. In this study, GTN caused a decrease in...

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Main Authors: Inayat-Hussain, S.H., Chan, K.M., Rajab, N.F., Din, L.B., Chow, S.C., Kizilors, A., Farzaneh, F., Williams, G.T.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828539/
https://ncbi.nlm.nih.gov/pubmed/20026395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2009.12.010
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