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IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway

BACKGROUND: Activation of the transcription factor NF-κB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IκB proteins. The IKK complex is comprised of two catalytic subunits, IKKα and IKKβ, and a regulatory p...

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Bibliografske podrobnosti
Main Authors: Adli, Mazhar, Merkhofer, Evan, Cogswell, Patricia, Baldwin, Albert S.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828475/
https://ncbi.nlm.nih.gov/pubmed/20195534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009428
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