EVIDENCE FOR ALTERED ACTIVITY OF THE IL-6 PATHWAY IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

BACKGROUND: Interleukin 6 (IL-6) activates Th17 cells and regulates the response of B-lymphocytes and T regulatory cells. The IL-6 receptor and the membrane protein, gp130, form an active signaling complex that signals through STAT3 and other signaling molecules. Both the IL-6 receptor (IL-6R) and g...

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Main Authors: Peters, Anju T., Kato, Atsushi, Zhang, Ning, Conley, David B., Suh, Lydia, Tancowny, Brian, Carter, Derek, Carr, Tara, Radtke, Michael, Hulse, Kathryn E., Seshadri, Sudarshan, Chandra, Rakesh, Grammer, Leslie C., Harris, Kathleen E., Kern, Robert, Schleimer, Robert P.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828355/
https://ncbi.nlm.nih.gov/pubmed/20159251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2009.10.072
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