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Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

A new series of 2-thioether-benzothiazoles has been synthesized and evaluated for JNK inhibition. The SAR studies led to the discovery of potent, allosteric JNK inhibitors with selectivity against p38.

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書誌詳細
主要な著者: De, Surya K., Chen, Li-Hsing, Stebbins, John L., Machleidt, Thomas, Riel-Mehan, Megan, Dahl, Russell, Chen, Vida, Yuan, Hongbin, Barile, Elisa, Emdadi, Aras, Murphy, Ria, Pellecchia, Maurizio
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828351/
https://ncbi.nlm.nih.gov/pubmed/19282190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.02.046
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