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GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback

Superoxide (O(2)(−) ) enhances tubuloglomerular feedback (TGF) by scavenging nitric oxide at the macula densa (MD). The primary source of O(2)(−) in the MD during TGF is NADPH oxidase, which is activated by membrane depolarization. While Rac, a small GTP-binding protein, has been shown to enhance NA...

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Hlavní autoři: Liu, Ruisheng, Juncos, Luis A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828178/
https://ncbi.nlm.nih.gov/pubmed/20007513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00622.2009
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