Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors

Nicotinic acetylcholine (nACh) and 5-hydroxytryptamine type 3 (5-HT(3)) receptors are cation-selective ion channels of the pentameric ligand-gated ion channel (pLGIC) superfamily. Multiple lines of evidence adduced over the last 30 years indicate that the lining of the channel of such receptors is f...

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Bibliographic Details
Main Authors: Peters, John A, Cooper, Michelle A, Carland, Jane E, Livesey, Matthew R, Hales, Tim G, Lambert, Jeremy J
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2010
Subjects:
Symposium Section Reviews: Cys-Loop Ligand-Gated Ion Channels and Receptors
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828133/
https://ncbi.nlm.nih.gov/pubmed/19933751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.183137
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