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The Regulation of the p53-mediated Stress Response by MDM2 and MDM4
Exquisite control of the activity of p53 is necessary for mammalian survival. Too much p53 is lethal, whereas too little permits tumorigenesis. MDM2 and MDM4 are structurally related proteins critical for the control of p53 activity during development, homeostasis, and the response to stress. These...
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2010
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2827903/ https://ncbi.nlm.nih.gov/pubmed/20182601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a000968 |
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