UOK 262: Fumarate Hydratase (-/-) Hereditary Leiomyomatosis Renal Cell Carcinoma: In Vitro and In Vivo Model of an Aberrant Energy Metabolic Pathway in Human Cancer

Energy deregulation and abnormalities of tumor cell metabolism are critical issues in our understanding of cancer. Hereditary leiomyomatosis renal cell carcinoma (HLRCC) is an aggressive form of RCC characterized by germline mutation of the Krebs cycle enzyme, fumarate hydratase (FH), and is known t...

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Auteurs principaux: Yang, Youfeng, Valera, Vladimir A., Padilla-Nash, Hesed M., Sourbier, Carole, Vocke, Cathy D., Vira, Manish A., Abu-Asab, Mones S., Bratslavsky, Gennady, Tsokos, Maria, Merino, Maria J., Pinto, Peter A., Srinivasan, Ramaprasad, Ried, Thomas, Neckers, Len, Linehan, W. Marston
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827193/
https://ncbi.nlm.nih.gov/pubmed/19963135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergencyto.2009.08.018
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