Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

Chromosomes can be specifically stained in metaphase spreads and interphase nuclei by in situ hybridization with entire chromosome-specific DNA libraries. Unlabeled human genomic DNA is used to inhibit the hybridization of sequences in the library that bind to multiple chromosomes. The target chromo...

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Bibliografiska uppgifter
Huvudupphovsmän: Pinkel, D, Landegent, J, Collins, C, Fuscoe, J, Segraves, R, Lucas, J, Gray, J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1988
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC282679/
https://ncbi.nlm.nih.gov/pubmed/2973607
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