Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

Chromosomes can be specifically stained in metaphase spreads and interphase nuclei by in situ hybridization with entire chromosome-specific DNA libraries. Unlabeled human genomic DNA is used to inhibit the hybridization of sequences in the library that bind to multiple chromosomes. The target chromo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pinkel, D, Landegent, J, Collins, C, Fuscoe, J, Segraves, R, Lucas, J, Gray, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282679/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2973607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.23.9138
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