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Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

We describe the isolation and the sequence of the gene for the bifunctional enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS; EC 1.5.1.3 and EC 2.1.1.45, respectively) from two pyrimethamine-resistant clones of Plasmodium falciparum, HB3 and 7G8. We have also derived the sequence of the...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Cowman, A F, Morry, M J, Biggs, B A, Cross, G A, Foote, S J
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1988
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282673/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3057499/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.23.9109
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