Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South America indicates that resistance to pyrimethamine, an antifolate used in the treatment of malaria, results from point mutations in the gene encoding dihydrofolate reducta...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Peterson, D S, Walliker, D, Wellems, T E
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1988
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC282674/
https://ncbi.nlm.nih.gov/pubmed/2904149
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