Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South America indicates that resistance to pyrimethamine, an antifolate used in the treatment of malaria, results from point mutations in the gene encoding dihydrofolate reducta...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Peterson, D S, Walliker, D, Wellems, T E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282674/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2904149/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.23.9114
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