Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

BACKGROUND: Mitochondrial dysfunction and degradation takes a central role in current paradigms of neurodegeneration in Parkinson's disease (PD). Loss of DJ-1 function is a rare cause of familial PD. Although a critical role of DJ-1 in oxidative stress response and mitochondrial function has be...

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Auteurs principaux: Krebiehl, Guido, Ruckerbauer, Sabine, Burbulla, Lena F., Kieper, Nicole, Maurer, Brigitte, Waak, Jens, Wolburg, Hartwig, Gizatullina, Zemfira, Gellerich, Frank N., Woitalla, Dirk, Riess, Olaf, Kahle, Philipp J., Proikas-Cezanne, Tassula, Krüger, Rejko
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826413/
https://ncbi.nlm.nih.gov/pubmed/20186336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009367
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