The mouse mutation “thrombocytopenia and cardiomyopathy” (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia

The spontaneous mouse mutation “thrombocytopenia and cardiomyopathy” (trac) causes macrothrombocytopenia, prolonged bleeding times, anemia, leukopenia, infertility, cardiomyopathy, and shortened life span. Homozygotes show a 20-fold decrease in platelet numbers and a 3-fold increase in platelet size...

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Detalhes bibliográficos
Main Authors: Chase, Thomas H., Lyons, Bonnie L., Bronson, Roderick T., Foreman, Oded, Donahue, Leah Rae, Burzenski, Lisa M., Gott, Bruce, Lane, Priscilla, Harris, Belinda, Ceglarek, Uta, Thiery, Joachim, Wittenburg, Henning, Thon, Jonathan N., Italiano, Joseph E., Johnson, Kenneth R., Shultz, Leonard D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826237/
https://ncbi.nlm.nih.gov/pubmed/19846887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-219808
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