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The missense mutation in Abcg5 gene in spontaneously hypertensive rats (SHR) segregates with phytosterolemia but not hypertension

BACKGROUND: Sitosterolemia is a recessively inherited disorder in humans that is associated with premature atherosclerotic disease. Mutations in ABCG5 or ABCG8, comprising the sitosterolemia locus, STSL, are now known to cause this disease. Three in-bred strains of rats, WKY, SHR and SHRSP, are know...

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Detaylı Bibliyografya
Asıl Yazarlar: Chen, Jianliang, Batta, Ashok, Zheng, Shuqin, Fitzgibbon, Wayne R, Ullian, Michael E, Yu, Hongwei, Tso, Patrick, Salen, Gerald, Patel, Shailendra B
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190168/
https://ncbi.nlm.nih.gov/pubmed/16026620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-6-40
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