Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8(+) T cells and characterize the progression of MGUS to multiple myeloma

We hypothesized that progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) reflects the escape of transformed plasma cells from T-cell recognition because of impaired antigen processing-presenting machinery (APM). We studied plasma cells and CD8(+) T cells...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Racanelli, Vito, Leone, Patrizia, Frassanito, Maria Antonia, Brunetti, Claudia, Perosa, Federico, Ferrone, Soldano, Dammacco, Franco
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826230/
https://ncbi.nlm.nih.gov/pubmed/20008301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-228676
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares