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Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8(+) T cells and characterize the progression of MGUS to multiple myeloma
We hypothesized that progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) reflects the escape of transformed plasma cells from T-cell recognition because of impaired antigen processing-presenting machinery (APM). We studied plasma cells and CD8(+) T cells...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2826230/ https://ncbi.nlm.nih.gov/pubmed/20008301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-228676 |
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