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A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.

A coding mutation in the human insulin gene (His-B10----Asp) is associated with familial hyperproinsulinemia. To model this syndrome, we have produced transgenic mice that express high levels of the mutant prohormone in their islets of Langerhans. Strain 24-6 mice, containing about 100 copies of the...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Carroll, R J, Hammer, R E, Chan, S J, Swift, H H, Rubenstein, A H, Steiner, D F
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282623/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3057496/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.23.8943
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